Joint Research & Development

NAGASE Group is
looking for a partner for
joint development & research in
the industry of biotechnology.

NAGASE Group has the technologies of micro-organisms,

fermentation, enzymes and enzyme reactants.

Our biotechnology is an eco-friendly technologies that utilizes the power of nature such as microorganisms and enzymes.
We will work to create "sustainable businesses" by solving the needs and issues of our customers and society,

such as the development of high-value-added materials that utilize biomass

raw materials and the conversion of chemical products to green chemicals.

Biotechnology is applied in
various fields all over the world.

Nagase Group has been engaged in businesses that utilize biotechnology,

mainly in the fields of food, healthcare, enzymes, and chemicals.

Biotech Industry Biotech Industry Biotech Industry

Food &

  • Carbohydrate Sugar
  • Enzyme
  • Food additive
  • Functional food
  • Nutrition
  • Flavor


  • Household
  • Cosmetics
  • Fragrance


  • Medical
  • Pharmacy


  • Fertilizer
  • Agrochemical
  • Seed


  • Chemical
  • Electronics
  • Polymer
  • Textile
  • Fuel
Enzyme reactants

  • Trehalose (improves food properties)
  • Isomaltodextrin
  • (improves gut microbiota)
  • Ascorbic acid 2-glucoside (skin brightening)
  • Glucosyl hesperidin (improves blood flow)
  • Phosphatidylserine (improves brain function)
  • Lysophosphatidic acid
  • (promotes of ceramide production)
  • Polymer
  • Lactic acid bacteria
  • Agricultural fungus
Products by fermentation
  • Pullulan (adhesive / coating agents)
  • Trehandierin (anti-aging)
  • Ergothioneine (anti-oxidant)
  • Labyrinthulea DNA
  • (improves brain function/decreases triglyceride)
Functional protein
  • Water repellent material
  • Industrial enzymes
  • Actinomycete-derived enzyme

Bio-technology Platform

Biotech Platform Biotech Platform Biotech Platform
  • ・Micro-organism screening
  • ・Gene screening
  • ・Enzyme screening
  • ・Genetic modification
  • ・Bacterial breeding
  • ・Metabolic engineering
Valuation analysis
  • ・Extract and purify
  • ・Functionally analysis
  • ・Components analysis
  • ・Industrial scale production
  • ・Production by enzymes
  • ・GMO culturing

One-stop development
end to end

We possess various biotechnology based on "micro-organisms", "fermentation", "enzymes" and "enzyme reactants".
We would like to propose the joint development of high value-added materials and green chemicals by bioprocesses that utilize those technologies.

Please contact us if you have
any of the following projects.


Development of sustainable materials that utilize microbial fermentation and enzymes


Development of new business that utilizes biomass raw materials


Development of changing the production from the traditional chemical production to bio-tech process


Any other development related to bio-technologies

<Case Study>

Commercialization of Ergothioneine

Ergothioneine is a rare natural amino acid found in trace amounts in mushrooms and other organisms, with excellent antioxidant properties and properties which improve brain function. It has high potential as a next-generation functional material and it is anticipated that it could help with neurodegenerative diseases (Alzheimer's and Parkinson's), depression, skin aging due to ultraviolet light (wrinkles and spots), cataracts, and glycation stress.

Through Nagase R&D Center research with the unique fermentation technology of the NAGASE Group as a core technology, a revolutionary fermentation process was established achieving one of the highest production efficiency levels using microorganisms in the world*. Using the producing strain developed, commercialization will be carried out through applications in the field of life sciences such as health foods, cosmetics, and pharmaceuticals.

*See here for details:

Sustainable DHA

Nagase Group has succeeded in developing sustainable docosahexaenoic acid (DHA), which has a low environmental impact.

Omega 3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are often used in health foods and supplements, are being consumed all over the world. It is mainly produced by extraction and refining from finite marine resources, and its environmental load has become a social problem.
On the other hand, Labyrinthulea, a microorganism classified as a microalgae, is known to accumulate highly unsaturated fatty acids such as docosahexaenoic acid (DHA) and docosapentaenoic acid in the body.
In addition, DHA is a substance that is very easily oxidized, but it has been reported that Labyrinthulea also accumulates carotenoids such as astaxanthin, which has high antioxidant power, and it is possible to produce more stable DHA.

Nagase Group has developed DHA that can be produced at high concentration and low cost by utilizing the power of Labyrinthulea and the group's unique microbial breeding technology.
These technologies make it possible to produce and provide high-value-added DHA while preserving marine resources. Even now, we are continuing to improve the sustainable production process, such as using sugar cane molasses as a medium raw material.

Nagase Group will continue to provide solutions that contribute to the SDGs, aiming for a safe, secure and warm society where people can live comfortably.

NAGASE Group will contribute to a sustainable

world where people live with peace of mind

by those biotechnology.